In conversations with global leaders in cardiology, we continue to challenge traditional paradigms in the diagnosis and management of ischemic heart disease — moving beyond stenosis to fully understand the spectrum of angina.

In this episode, Prof. Javier Escaned guides us through the “dark side of the moon” of coronary artery disease — INOCA, vasomotor disorders, and the underrecognized burden of non-obstructive angina. We explore the role of advanced imaging, the need to stratify endotypes, and how the 2025 Lancet Commission’s focus on atherosclerosis fits — or doesn’t — within this broader clinical reality.

If you’re rethinking how we define, detect, and treat angina in its many forms — this conversation is essential.